Ultra Creamy Cajun Chicken Penne is the kind of bold, satisfying meal that hits all the right notes. Tender chicken coated in zesty Cajun spice, tossed with perfectly cooked penne and smothered in a rich, velvety sauce made with cream cheese and melty mozzarella — it’s the ultimate comfort food with attitude. Whether you’re craving a cozy night in or planning a casual dinner with friends, this pasta brings the heat in the most delicious way.
It’s more than just a pasta recipe; it’s a full experience. Every bite brings that creamy texture you love, layered with smoky paprika, peppery Cajun flavor, and a little kick of heat from red pepper flakes. It’s quick enough for a weeknight but tastes like a restaurant-quality indulgence. If you love spicy, cheesy, creamy pasta dishes, this one belongs in your rotation.
Let’s dive into everything you need to know to master this creamy, spicy wonder — from why you’ll love it to the step-by-step instructions, tips, variations, and more.
Why You’ll Love This Recipe
This Cajun Chicken Penne is a must-try for any pasta fan. Here’s why it stands out:
- Bold Flavor – The Cajun spice blend delivers smoky heat and depth that keeps each bite interesting.
- Rich & Creamy – Cream cheese, heavy cream, and two cheeses combine for a luscious sauce that clings to every noodle.
- Quick Weeknight Dinner – Ready in about 30 minutes, this recipe is both speedy and satisfying.
- Customizable Heat – Dial the spice up or down depending on your preference.
- One-Pan Sauce – Less cleanup and more flavor thanks to everything happening in one skillet.
- Hearty and Filling – Packed with protein and carbs, it’s a complete, comforting meal.
Preparation and Cooking Time
Here’s how long it takes to bring this creamy Cajun pasta to the table:
- Preparation Time: 10 minutes
- Cooking Time: 20 minutes
- Total Time: About 30 minutes
That’s all you need to transform a handful of ingredients into a spicy, cheesy masterpiece.
Ingredients
- 12 oz penne pasta
- 2 boneless, skinless chicken breasts, cut into strips
- 1 tbsp Cajun seasoning (plus extra for garnish)
- 1 tbsp olive oil
- 1 cup heavy cream
- 4 oz cream cheese, softened
- 1 cup mozzarella, shredded
- ¼ cup Parmesan cheese
- ½ tsp garlic powder
- ½ tsp onion powder
- ½ tsp smoked paprika
- ¼ tsp crushed red pepper flakes (plus more for garnish)
- Salt to taste
- Chopped parsley (optional)
Step-by-Step Instructions
Follow these simple steps to get that perfect creamy Cajun pasta on your plate:
- Cook the Pasta
Bring a large pot of salted water to a boil. Add penne and cook until al dente according to package directions. Drain and set aside. - Season and Cook the Chicken
Toss chicken strips in Cajun seasoning. Heat olive oil in a large skillet over medium heat and sauté chicken until golden and cooked through. Remove and set aside. - Make the Creamy Base
In the same skillet, add softened cream cheese and heavy cream. Stir until the mixture becomes smooth and melted. - Season the Sauce
Add garlic powder, onion powder, smoked paprika, and crushed red pepper flakes. Stir to combine and bring the sauce to a gentle simmer. - Melt the Cheese
Add shredded mozzarella and Parmesan to the sauce, stirring until everything is fully melted and the sauce is ultra creamy. - Add Back the Chicken
Return cooked chicken strips to the pan and let everything simmer together for 2–3 minutes to absorb the flavors. - Combine with Pasta
Fold in the cooked penne, stirring to coat the pasta evenly with the creamy Cajun sauce. - Garnish and Serve
Sprinkle extra Cajun seasoning and red pepper flakes on top. Add chopped parsley if desired. Serve hot!
How to Serve
Here’s how to make this pasta feel even more special:
- Use a Shallow Pasta Bowl: It helps trap the sauce and keeps it warm longer.
- Serve with Garlic Bread: A crunchy slice is perfect for soaking up the creamy sauce.
- Add a Side Salad: Something fresh and tangy, like arugula or spinach with lemon vinaigrette, balances the richness.
- Top with Extra Cheese: A final dusting of Parmesan or mozzarella before serving adds that wow factor.
Additional Tips
- Use Room Temp Cream Cheese: It melts more smoothly into the sauce.
- Don’t Skip the Cajun Seasoning: It’s the heart of the flavor here — bold, smoky, and a little spicy.
- Balance the Heat: Adjust red pepper flakes based on your spice tolerance.
- Want More Veggies? Add sautéed bell peppers, mushrooms, or spinach to bulk it up.
- Make it Extra-Creamy: Stir in an extra splash of cream if you want it looser and richer.
Recipe Variations
Switch it up depending on what you have on hand or who you’re cooking for:
- Shrimp Version: Swap chicken for shrimp for a classic Cajun seafood twist.
- Vegetarian: Skip the meat and add mushrooms, zucchini, or broccoli.
- Extra Protein: Use chicken thighs or sausage for a different flavor.
- Low Carb Option: Serve the creamy Cajun chicken over steamed veggies or zucchini noodles.
Freezing and Storage
- Storage: Refrigerate leftovers in an airtight container for up to 3 days.
- Freezing: Freeze in portions using freezer-safe containers. Best eaten within 1 month.
- Reheating: Warm on the stove with a splash of cream or milk to rehydrate the sauce.
Special Equipment
These basic kitchen tools make it easier:
- Large Skillet or Sauté Pan
- Pot for Boiling Pasta
- Wooden Spoon or Silicone Spatula
- Measuring Cups and Spoons
- Sharp Knife and Cutting Board
Frequently Asked Questions
Can I use rotisserie chicken instead of cooking from scratch?
Absolutely! Just shred it and toss it in the sauce when you would return the cooked chicken.
Is there a dairy-free version of this dish?
Yes, you can substitute dairy-free cream, cream cheese, and shredded vegan cheese.
How spicy is it?
It has a moderate kick. Omit the crushed red pepper for milder flavor or increase it for extra heat.
Can I make it ahead of time?
You can make the sauce and pasta separately, then combine and reheat when ready to serve.
Conclusion
🌶️ Ultra Creamy Cajun Chicken Penne is everything you want in a comforting pasta dish — rich, bold, spicy, and oh-so-creamy. It’s easy enough for a busy weeknight, but flavorful enough to serve guests. If you love cheesy sauces with a Cajun kick, this recipe will hit the spot every time. So grab your pan, fire up the stove, and treat yourself to a bowl of saucy goodness tonight!
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Ultra Creamy Cajun Chicken Penne: The Ultimate Comfort Dish with a Kick
- Total Time: 30 minutes
- Yield: 4 servings 1x
Description
Tender Cajun-seasoned chicken, rich cream cheese sauce, and perfectly cooked penne pasta make this ultra creamy dish the ultimate spicy comfort food.
Ingredients
- 12 oz penne pasta
- 2 boneless, skinless chicken breasts, cut into strips
- 1 tbsp Cajun seasoning (plus extra for garnish)
- 1 tbsp olive oil
- 1 cup heavy cream
- 4 oz cream cheese, softened
- 1 cup mozzarella, shredded
- ¼ cup Parmesan cheese
- ½ tsp garlic powder
- ½ tsp onion powder
- ½ tsp smoked paprika
- ¼ tsp crushed red pepper flakes (plus more for garnish)
- Salt to taste
- Chopped parsley (optional)
Instructions
- Bring a large pot of salted water to a boil. Add penne and cook until al dente. Drain and set aside.
- Toss chicken in Cajun seasoning. Heat olive oil in a skillet over medium heat and cook chicken until golden and cooked through. Remove and set aside.
- In the same skillet, add cream cheese and heavy cream. Stir until smooth and melted.
- Add garlic powder, onion powder, smoked paprika, and red pepper flakes. Stir and simmer.
- Add mozzarella and Parmesan. Stir until fully melted and creamy.
- Return chicken to the skillet and simmer for 2–3 minutes.
- Add cooked penne and stir to coat with sauce.
- Garnish with Cajun seasoning, red pepper flakes, and parsley. Serve hot.
Notes
Adjust spice level to taste. For extra veggies, try adding bell peppers or spinach. Use room temp cream cheese for best results.
- Prep Time: 10 minutes
- Cook Time: 20 minutes
- Category: Dinner
- Method: Stovetop
- Cuisine: Cajun
Nutrition
- Serving Size: 1 plate
- Calories: 680
- Sugar: 3g
- Sodium: 850mg
- Fat: 42g
- Saturated Fat: 21g
- Unsaturated Fat: 18g
- Trans Fat: 0g
- Carbohydrates: 38g
- Fiber: 2g
- Protein: 39g
- Cholesterol: 155mg
Keywords: cajun chicken pasta, creamy pasta, spicy penne, comfort food